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SKI V
CAS No. 24418-86-8
SKI V( —— )
Catalog No. M21983 CAS No. 24418-86-8
SKI V is a potent and noncompetitive non-lipid sphingosine kinase (SPHK; SK) inhibitor (GST-hSK,IC50 : 2 μM), and is a PI3K inhibitor(hPI3k,IC50 : 6 μM), induces apoptosis and has antitumor activity
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 208 | Get Quote |
|
| 10MG | 332 | Get Quote |
|
| 25MG | 560 | Get Quote |
|
| 50MG | 797 | Get Quote |
|
| 100MG | 1071 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameSKI V
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NoteResearch use only, not for human use.
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Brief DescriptionSKI V is a potent and noncompetitive non-lipid sphingosine kinase (SPHK; SK) inhibitor (GST-hSK,IC50 : 2 μM), and is a PI3K inhibitor(hPI3k,IC50 : 6 μM), induces apoptosis and has antitumor activity
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DescriptionSKI V is a potent and noncompetitive non-lipid sphingosine kinase (SPHK; SK) inhibitor (GST-hSK,IC50 : 2 μM), and is a PI3K inhibitor(hPI3k,IC50 : 6 μM), induces apoptosis and has antitumor activity.
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In VitroSKI V has weak activity toward ERK2 (IC50 of 80 μM for hERK2) and does not inhibit PKC-α.SKI V (10 μM; for 24 hours) inhibits cancer cell proliferation and induces apoptosis. SKI V (0.2, 1, 5 μM; pretreated for 1 hour) decreases phospho-Akt and phospho-MEK levels. Near-confluent cultures of JC cells are serum-starved for 16 hours, followed by pretreatment SKI V for 1 hour. SKI V has IC50s for inhibition of sphingosine kinase (SK) and tumor cell proliferation of ～2 μM. SKI V (20 μg/ml) inhibits not only purified but endogenous SK in in MDA-MB-231 cells.SKI V (0.2, 1, 5 μM) inhibits intracellular S1P formation in JC cells in a dose-dependent fashion. Cell Proliferation Assay Cell Line:T24 tumor cells Concentration:10 μM Incubation Time:For 24 hours Result:Inhibited cancer cell proliferation.Apoptosis Analysis Cell Line:T24 tumor cells Concentration:10 μM Incubation Time:For 24 hours Result:Induced apoptosis.Western Blot AnalysisCell Line:JC cells Concentration:0.2, 1, 5 μM Incubation Time:Pretreated for 1 hour Result:Decreased phospho-Akt and phospho-MEK levels.
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In VivoSKI V (75 mg/kg; i.p.; days 1, 5, 9, 15) significantly lowers tumor growth (>50% decreased at day 18) than control animals. Animal Model:6-8 weeks old BALB/c female mice with JC mammary adenocarcinoma cellsDosage:75 mg/kg Administration:IP; days 1, 5, 9, 15 Result:Tumor growth was significantly lower (>50% decreased at day 18) than tumor growth in control animals.
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Synonyms——
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PathwayGPCR/G Protein
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TargetS1P Receptor
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RecptorSphK|PI3K
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Research Area——
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Indication——
Chemical Information
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CAS Number24418-86-8
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Formula Weight254.24
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Molecular FormulaC15H10O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (196.66 mM)
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SMILESOc1ccc(\C=C2\Oc3ccccc3C2=O)cc1O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. French KJ, et al. Antitumor activity of sphingosine kinase inhibitors. J Pharmacol Exp Ther. 2006 Aug;318(2):596-603.2. French KJ, et al. Discovery and evaluation of inhibitors of human sphingosine kinase. Cancer Res. 2003 Sep 15;63(18):5962-9.
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